Meligamet, 50/850 Mg - 60 Tablets

Product Name

• Meligamet, 50/850 Mg - 60 Tablets

Scientific Name

• Sitagliptin / Metformin Hydrochloride

Category Of Meligamet

• Antidiabetic (DPP-4 Inhibitor + Biguanide Combination)

Mechanism Of Action Of Sitagliptin/Metformin

• Sitagliptin inhibits the DPP-4 enzyme, increasing incretin levels, enhancing insulin release, and reducing glucagon secretion.
• Metformin decreases hepatic glucose production and improves insulin sensitivity, helping to control blood sugar levels.
• The combination provides complementary mechanisms to improve glycemic control in type 2 diabetes mellitus patients.

Therapeutic Indications Of Meligamet

• Treatment of type 2 diabetes mellitus to improve glycemic control in adults inadequately controlled on metformin alone or those already treated with sitagliptin and metformin separately.

Method Of Administration Of Meligamet

• Take orally with meals to minimize gastrointestinal side effects.
• Swallow the tablet whole without crushing or chewing.
• The dose should be individualized according to the patient's current regimen, effectiveness, and tolerability.

Undesirable Side Effects Of Meligamet

May cause:

1. Nausea
2. Diarrhea
3. Headache
4. Upper respiratory tract infection
5. Low blood sugar (when used with insulin or sulfonylureas)
6. Metallic taste
7. Fatigue

Pregnancy & Breastfeeding Precaution While Taking Meligamet

• Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• It is unknown if sitagliptin passes into breast milk; caution is advised when breastfeeding.

Warnings & Special Precautions While Taking Meligamet

• Monitor kidney function before starting and periodically during treatment.
• Use with caution in patients with a history of pancreatitis.
• Risk of lactic acidosis with metformin; discontinue if suspected.
• Temporarily discontinue before surgical procedures or radiologic studies involving iodinated contrast.

Storage Conditions Of Meligamet

• Store below 30°C.
• Keep in the original package to protect from moisture.
• Keep out of reach of children.