Ramipril Sandoz 5 Mg, For High Blood Pressure - 20 Tablets

Product Name

• Ramipril Sandoz 5 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 20 Tablets

Scientific Name

• Ramipril 5 Mg Tablets

Category Of Ramipril Sandoz 5 Mg Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Ramipril

• Ramipril belongs to Angiotensin-converting-enzyme inhibitors which are a class of medication used primarily for the treatment of high blood pressure and heart failure. They work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.
• In addition, Ramipril blocks the conversion of angiotensin I to angiotensin II and prevents the degradation of vasodilator prostaglandins, thereby inhibiting systemic vasoconstriction, regulated by angiotensin II, and promoting systemic vasodilation.

Therapeutic Indications Of Ramipril Sandoz 5 Mg Tablets

• To treat high blood pressure (hypertension): high blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
• To reduce the risk of you having a heart attack or stroke
• To reduce the risk or delay the worsening of kidney problems
• To treat your heart when it cannot pump enough blood to the rest of your body (heart failure)
• Treatment following a heart attack (myocardial infarction) is complicated with heart failure.

Method Of Administration Of Ramipril Sandoz 5 Mg Tablets

• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• Swallow the tablet with a drink of water.
• Do not crush or chew the tablets.
• Treatment of high blood pressure:

1. The usual starting dose is 1.25 mg or 2.5 mg once daily. Your doctor will adjust the amount you take until your blood pressure is controlled.
2. The maximum dose is 10 mg once daily.
3. If you are already taking diuretics (water tablets), your doctor may stop or reduce the amount of the diuretic you take before beginning treatment with ramipril.

• To reduce the risk of you having a heart attack or stroke:

1. The usual starting dose is 2.5 mg once daily. Your doctor may then decide to increase the amount you take.
2. The usual dose is 10 mg once daily.

• Treatment to reduce or delay the worsening of kidney problems:

1. You may be started on a dose of 1.25 mg or 2.5 mg once daily. Your doctor will adjust the amount you are taking.
2. The usual dose is 5 mg or 10 mg once daily.

• Treatment of heart failure:

1. The usual starting dose is 1.25 mg once daily. Your doctor will adjust the amount you take.
2. The maximum dose is 10 mg daily.
3. Two administrations per day are preferable.

• Treatment after you have had a heart attack:

1. The usual starting dose is 1.25 mg once daily to 2.5 mg twice daily. Your doctor will adjust the amount you take.
2. The usual dose is 10 mg daily.
3. Two administrations per day are preferable

• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Ramipril Sandoz 5 Mg Tablets

• Headache or feeling tired
• Feeling dizzy. This is more likely to happen when you start taking Ramipril or start taking a higher dose
• Fainting, hypotension (abnormally low blood pressure), especially when you stand or sit up quickly
• Dry tickly cough, inflammation of your sinuses (sinusitis) or bronchitis, shortness of breath
• Stomach or gut pain, diarrhea, indigestion, feeling, or being sick
• Skin rash with or without raised area
• Chest pain
• Cramps or pain in your muscles
• Blood tests show more potassium than usual in your blood.
• Balance problems (vertigo)
• Itching and unusual skin sensations such as numbness, tingling, pricking, burning, or creeping on your skin (paresthesia)
• Loss or change in the way things taste
• Sleep problems
• Feeling depressed, anxious, more nervous than usual, or restless
• Blocked nose, difficulty breathing, or worsening of asthma
• Swelling in your gut which is called “intestinal angioedema” presenting with symptoms like abdominal pain, vomiting, and diarrhea.

Pregnancy & Breastfeeding Precautions While Taking Ramipril Sandoz 5 Mg Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

• To measure blood pressure correctly:

1. Don’t eat or drink anything 30 minutes before you take your blood pressure.
2. Empty your bladder before your reading.
3. Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
4. Put both feet flat on the ground and keep your legs uncrossed.
5. Rest your arm with the cuff on a table at chest height.
6. Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
7. Do not talk while your blood pressure is being measured.

• You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

1. Lose extra pounds and watch your waistline
2. Exercise regularly
3. Eat a healthy diet
4. Reduce sodium in your diet
5. Quit smoking
6. Reduce caffeine
7. Reduce your stress
8. Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron Blood Pressure Measuring Device
9. See your doctor regularly

Warnings & Special Precautions while Taking Ramipril Sandoz 5 Mg Tablets

• Talk to your doctor or pharmacist before taking Ramipril:

1. If you have heart, liver, or kidney problems
2. If you have lost a lot of body salts or fluids through being sick (vomiting), having diarrhea, sweating more than usual, being on a low salt diet, taking diuretics for a long time
3. If you are going to have treatment to reduce your allergy to bee or wasp stings
4. If you are going to receive an anesthetic.
5. If you have high amounts of potassium in your blood (shown in blood test results)
6. If you are taking medicines or have conditions that may decrease sodium levels in your blood.
7. If you are taking medicines that may increase the risk of angioedema, such as mTOR inhibitors, vildagliptin, neprilysin (NEP) inhibitors, or sacubitril/valsartan.
8. If you have a collagen vascular disease such as scleroderma or systemic lupus erythematosus.
9. You must tell your doctor if you think that you are (or might become) pregnant. Ramipril is not recommended in the first 3 months of pregnancy and may cause serious harm to your baby after 3 months of pregnancy.
10. If you are taking any of the following medicines used to treat high blood pressure: an angiotensin II receptor blocker (ARBs), aliskiren.

• Tell your doctor if you are taking any of the following medicines. They can make Ramipril work less well:

1. Medicines used to relieve pain and inflammation such as ibuprofen or indometacin
2. Medicines used for the treatment of low blood pressure, shock, cardiac failure, asthma, or allergies such as ephedrine, noradrenaline, or adrenaline.
3. Tell your doctor if you are taking any of the following medicines. They can increase the chance of getting side effects if you take them with Ramipril:
4. Sacubitril/valsartan – used for treating a type of long-term (chronic) heart failure in adults.
5. Medicines used to relieve pain and inflammation (e.g. Non-Steroidal Anti- Inflammatory
6. Drugs (NSAIDs) such as ibuprofen or indometacin and aspirin)
7. Medicines for cancer (chemotherapy)
8. Medicines to stop the rejection of organs after a transplant such as a ciclosporin
9. Diuretics (water tablets) such as furosemide
10. Medicines that can increase the amount of potassium in your blood such as spironolactone, triamterene, amiloride, potassium salts
11. Steroid medicines such as prednisolone
12. Allopurinol (used to lower the uric acid in your blood)
13. Procainamide (for heart rhythm problems)
14. Temsirolimus (for cancer)

Storage Conditions Of Ramipril Sandoz 5 Mg Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

• Normal: Blood pressure numbers of less than 120/80 mm Hg
• Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
• Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
• Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
• Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Ramipril

• Ask your physician or pharmacist
• SFDA website at Information About Ramipril
• Visit Medscape at Information About Ramipril
• Visit Drugbank at Information About Ramipril
• Visit Drugs.com at Information About Ramipril