Blocks beta-adrenergic stimulation, beta receptors stimulate the heart and increase its rate, force of contraction & conductivity
Beta-blocker protects the heart from too much activity. This medicine works by affecting the body’s response to some nerve impulses, especially in the heart.
As a result, it slows down the heart rate and makes the heart more efficient at pumping blood around the body.
Nebivolol also facilitates NO release which helps in reducing peripheral vascular resistance and significantly increases stroke volume

Hypertension: High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions

For hypertension: Adults above 18 years old: the recommended dose is 5mg once daily.
For chronic heart failure: Adults above 18 years old: the recommended initial dose is 1.25mg daily. This may be increased after 1-2 weeks to half a tablet daily (2.5mg) and then to 1 tablet daily (5mg). This may be further increased to a maximum recommended dose of 2 tablets daily (10mg)
You can take it with or without food.
If you want to increase the dose for further reduction in blood pressure wait 2 weeks interval.
If renal or hepatic impairment starting dose is 2.5mg.
Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Stop taking Nebivolol and tell your doctor immediately or go to your nearest hospital emergency department if:

Whole-body allergic reaction, with generalized skin eruption (hypersensitivity reactions)
Rapid-onset swelling, especially around the lips, eyes, or of the tongue with sudden difficulty in breathing (angioedema).

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Don’t eat or drink anything 30 minutes before you take your blood pressure.
Empty your bladder before your reading.
Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
Put both feet flat on the ground and keep your legs uncrossed.
Rest your arm with the cuff on a table at chest height.
Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
Do not talk while your blood pressure is being measured.

You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

Acute exacerbation of coronary artery disease upon cessation of therapy: Do not abruptly discontinue.
Diabetes: Monitor glucose as β-blockers may mask symptoms of hypoglycemia.
Tell your doctor if you are taking any of the following medicines:

CYP2D6 enzyme inhibitors (fluoxetine, bupropion, paroxetine, amiodarone) may increase Nebivolol levels.
Reserpine or clonidine may produce an excessive reduction of sympathetic activity.
Both digitalis glycosides (digoxin, digitoxin) and β-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Verapamil- or diltiazem-type calcium channel blockers may cause excessive reductions in heart rate, blood pressure, and cardiac contractility.
Antacids (e.g. cimetidine), are used to treat excessive stomach acid. If you are being treated for excessive stomach acid, you should take nebivolol during a meal, and the antacid drug between meals.
Asthma medications, medications for a blocked nose (e.g. pseudoephedrine) or certain eye disorders such as glaucoma (increased pressure in the eye) or dilation of the pupil.

Store below 25°c
Don’t refrigerate
Keep this medicine out of the sight and reach of children.
Store in the original package to protect from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal: Blood pressure numbers of less than 120/80 mm Hg
Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

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