Product Name

Moduretic 50 Mg, Reduce Blood Pressure, Prevent Hypertension Complication - 30 Tablets

Scientific Name

Amiloride 5 Mg + Hydrochlorothiazide 50 Mg Tablets

Category Of Moduretic 50 Mg Tablets

Anti-Hypertensive Drugs

Mechanism Of Action Of Amiloride & Hydrochlorothiazide

Amiloride hydrochloride is a potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.
Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid.
Thus it increases urine excretion, which by turn decreases blood volume and finally blood pressure.
On long-term usage, thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance.

Therapeutic Indications Of Moduretic 50 Mg Tablets

To treat patients with high blood pressure (hypertension): High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
Also, used to treat water buildup in your body (edema) due to problems with your heart, kidneys, liver, or blood vessels.
To treat patients with heart failure: It usually occurs when the heart is unable to pump blood around the body properly.

Method Of Administration Of Moduretic 50 Mg Tablets

Take as indicated by your doctor.
Take with a glass of water.
High blood pressure:

The usual starting dose is half a tablet each day.
Your doctor may change your dose to one tablet given each day
Your doctor may spread out the dose or give it as a single dose

Heart failure:

The usual starting dose is half a tablet each day
Your doctor may change your dose
You should not take more than two tablets in a day

Fluid retention due to cirrhosis:

The usual starting dose is one tablet each day
Your doctor may change your dose
You should not take more than two tablets in a day

Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Moduretic 50 Mg Tablets

Purplish or reddish-brown spots, skin irritation, increased sensitivity to sunlight, and a nettle like rash (urticaria)
Headache when you stand quickly
Anemia: signs include unusual tiredness or loss of color in the lining of the eyes and skin around the eyes
Other blood disorders which can result in high temperature (fever), a sore throat, being unable to stop bleeding from a cut
Changes in the levels of various chemicals in the blood which are usually detected by blood or urine tests
Stomach and gut
Feeling sick (nausea) or being sick (vomiting), indigestion, diarrhea, constipation, stomach ache, stomach cramps, wind, bloated feeling, hiccups
Inflammation of the pancreas: signs may include feeling sick (nausea) and being sick (vomiting) with
Pain in the stomach area and back
Swelling of the glands that make saliva
Dry mouth
A bad taste in your mouth
Lack or loss of appetite
Difficulty breathing
Blocked nose
Cough
Feeling dizzy, feeling like you are spinning (vertigo), pins and needles
Feeling sleepy, or sometimes feeling that you cannot sleep
Stupor is a type of brain disorder called encephalopathy
Feeling nervous, confused, depressed, or restless
Tremors
Hair loss
An increase in the pressure in the eye which is usually picked up in eye examinations
Changes in vision
Ringing in the ears
Joint pain, pain in the fingers and toes, gout
Neck, shoulder, and back pain
Leg ache, muscle cramps
Difficulty or pain urinating, an increase in the amount of urine passed
Contractions of the bladder which can lead to an increase in how often you need to pass urine
Kidney disorders which may lead to a reduced amount of urine being passed
Passing urine at night, incontinence
Lower sex drive
Impotence

Pregnancy & Breastfeeding Precautions While Taking Moduretic 50 Mg Tablets

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Non-Pharmacological Treatments & Advice To Reduce Blood Pressure

To measure blood pressure correctly:

Don’t eat or drink anything 30 minutes before you take your blood pressure.
Empty your bladder before your reading.
Sit in a comfortable chair with your back supported for at least 5 minutes before your reading.
Put both feet flat on the ground and keep your legs uncrossed.
Rest your arm with the cuff on a table at chest height.
Make sure the blood pressure cuff is snug but not too tight. The cuff should be against your bare skin, not over clothing.
Do not talk while your blood pressure is being measured.

You will also find the following Non-Pharmacological treatments effective in blood pressure reduction:

Lose extra pounds and watch your waistline
Exercise regularly
Eat a healthy diet
Reduce sodium in your diet
Quit smoking
Reduce caffeine
Reduce your stress
Monitor your blood pressure at home using for example Beurer, Blood Pressure Monitor or Omron, Blood Pressure Measuring Device
See your doctor regularly

Warnings & Special Precautions while Taking Moduretic 50 Mg Tablets

Talk to your doctor or pharmacist before taking Hydrochlorothiazide & Amiloride hydrochloride if:

You have been told by your doctor you have high levels of uric acid, cholesterol, or triglycerides in your blood
You are taking digitalis such as digoxin
You are being given fluids by a tube inserted into one of your veins
You have recently suffered from severe vomiting or diarrhea
You have Systemic Lupus Erythematosus
You are elderly
You have gout
You have had skin cancer or if you develop an unexpected skin lesion during the treatment.

Treatment with hydrochlorothiazide, particularly long-term use with high doses, may increase the risk of some types of skin and lip cancer (non-melanoma skin cancer). Protect your skin from sun exposure and UV rays while taking Hydrochlorothiazide & Amiloride hydrochloride.
It is important to tell your doctor or pharmacist if you take:

Angiotensin-converting enzyme inhibitors (ACE inhibitors) such as enalapril used to treat high blood pressure or heart problems
Angiotensin II receptor antagonists such as losartan - used to treat high blood pressure or diabetics with kidney damage
Other medicines for high blood pressure
Medicines for diabetes such as insulin
Lithium: used for depression
Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin or ibuprofen: used to reduce a high temperature (fever), pain, or arthritis
Barbiturates: used to help you sleep or to reduce anxiety
Painkillers such as codeine, dihydrocodeine, dextropropoxyphene, diamorphine, morphine, pentazocine, and pethidine
Cholestyramine and colestipol - used to treat high cholesterol (hyperlipidemia)
Steroids - used to treat lots of different conditions such as rheumatism, arthritis, allergic conditions, skin problems, asthma, or a type of blood disorder
ACTH to test whether your adrenal glands are working properly
Medicines injected for allergic reactions such as adrenaline (also known as epinephrine)
Tacrolimus: used after a liver or kidney transplant to prevent rejection
Ciclosporin: used for rheumatoid arthritis or to prevent rejection after a transplant ‘non-depolarising’ muscle relaxants such as tubocurarine
Trilostane: used to treat breast cancer or overactive adrenal glands (such as in Conn’s syndrome, Cushing’s syndrome)

Storage Conditions Of Moduretic 50 Mg Tablets

Store below 25°c
Don’t refrigerate
Keep this medicine out of the sight and reach of children.
Store in the original package to protect from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Normal Range

Normal: Blood pressure numbers of less than 120/80 mm Hg
Elevated: is when readings consistently range from 120-129 systolic and less than 80 mm Hg diastolic.
Hypertension Stage 1: is when blood pressure consistently ranges from 130-139 systolic or 80-89 mm Hg diastolic.
Hypertension Stage 2: is when blood pressure consistently ranges at 140/90 mm Hg or higher.
Hypertensive crisis: This stage of high blood pressure requires medical attention. If your blood pressure readings suddenly exceed 180/120 mm Hg, wait five minutes and then test your blood pressure again. If your readings are still unusually high, contact your doctor immediately. You could be experiencing a hypertensive crisis.

For More Information About Amiloride & Hydrochlorothiazide

Ask your physician or pharmacist
Visit Medscape at Information About Amiloride & Hydrochlorothiazide
Visit Drugbank at Information About Amiloride & Hydrochlorothiazide
Visit Drugs.com at Information About Amiloride & Hydrochlorothiazide
SFDA website at Information About Amiloride & Hydrochlorothiazide

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