Actosmet 15/850, Reduce Blood Glucose Level & Prevent Diabetes Complications - 56 Tablets

Pioglitazone is a selective agonist at peroxisome proliferator-activated receptor-gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver.4,2 Activation of PPARγ increases the transcription of insulin-responsive genes involved in the control of glucose and lipid production, transport, and utilization.
Through this mechanism, pioglitazone both enhances tissue sensitivity to insulin and reduces the hepatic production of glucose
Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
Metformin decreases the intestinal absorption of glucose
Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

It is used to lower blood sugar levels in patients with diabetes mellitus type 2 (non-insulin-dependent). It is used when diet and exercising have failed to control your diabetes
Method Of Administration Of Actosmet 15/850 Tablets
Individualize the starting dose based on the patient’s current regimen and adjust the dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of pioglitazone 45 mg and metformin 2550 mg
Give in divided daily doses with meals to reduce the gastrointestinal effects due to metformin
Monitor patients for adverse events related to fluid retention after initiation and dose increases
Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
If you take more than you should, talk to a doctor or go to the hospital straight away.
If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Although the following side effects are not common in everyone, some patients may complain from:

If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding

All carbohydrates affect blood glucose levels so it’s important to know which foods contain carbohydrates. Choose the healthier foods that contain carbs and be aware of your portion sizes.
Eat less salt. Eating lots of salt can increase your risk of high blood pressure, which in turn increases the risk of heart diseases and stroke. And when you have diabetes, you’re already more at risk of all of these conditions.
Eat more fruit and vegetables. This can help you get the vitamins, minerals, and fiber your body needs every day to help keep you healthy.
You can always try low or zero-calorie sweeteners (also known as artificial sweeteners) to help you cut down sugar for example Steviana Sweetener or Tropicana Slim Sweetener
Don’t forget to keep moving. Being more physically active goes hand in hand with eating healthier.
Remember to measure your blood glucose level continuously by using home monitor like Accu-Check, Instant, Blood Glucose Monitor
Thiozac Capsules & Neurobion Tablets will help you to reduce neuropathy induced by diabetes
If you experience symptoms of hypoglycemia such as weakness, dizziness, increased sweating, fast heart beating, vision disorders, or difficulty in concentration, it usually helps to eat or drink something containing sugar.

Fluid retention may occur and can exacerbate or lead to congestive heart failure When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia
Fractures: Increased incidence in female patients Metformin may lower vitamin B12 levels. Monitor hematologic parameters annually
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medications including over-the-counter non-prescription medicines, prescription medicines, herbal supplements, vitamins, and supplements.

Store below 25°c
Don’t refrigerate
Keep this medicine out of the sight and reach of children.
Store in the original package to protect from moisture.
Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.

Random blood sugar test: A blood sample will be taken at a random time. Regardless of when you last ate, a blood sugar level of 200 milligrams per deciliter (mg/dL) or higher suggests diabetes. A blood sugar level of less than 140 mg/dL is normal. A reading between 140 and 199 mg/dL indicates prediabetes
Fasting blood sugar test. A blood sample will be taken after an overnight fast. A fasting blood sugar level of less than 100 mg/dl is normal. A fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes. If it's 126 mg/dL or higher on two separate tests, you may have diabetes.
Oral glucose tolerance test: For this test, you fast overnight, and the fasting blood sugar level is measured. Then you drink a sugary liquid, and blood sugar levels are tested periodically for the next two hours.

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